EDITORIALS
131 DRUG DEVELOPMENT
Data sharing will pay dividends The pharmaceutical industry needs to stay on track over transparency
131 VIOLENCE
Risk management
Threat assessments can help protect employees at their place of work
132 WAR
Conflict of interest
Science can have a mutually beneficial relationship with war
WORLD VIEW
133 This was no Antarctic pleasure cruise Chris Turney
There was a clear scientific Basis for polar expedition
RESEARCH HIGHLIGHTS
134 SELECTIONS FROM THE
SCIENTIFIC LITERATURE
In vivo glia-to-neuron switch / Handy graphene / Dietary fibre link to asthma / Chemotherapy-provoked resistance / Sinkhole prediction
SEVEN DAYS
136 THE NEWS IN BRIEF
Cannabis goes on sale in Colorado / China joins ivory-crushing campaign / Alan Turing gets royal pardon /Asteroid followed from space to landfall
249 EQUALITY
Standing out
There's plenty of advice for LGBT
scientists contemplating a career in research — if you know where to look
251 TURNING POINT
Huffington Post blogger Eleni
Antoniadou sees artificial skin as an immediate goal in tissue engineeririg
139 REGENERATIVE MEDICINE Leaked documents reinforce
doubts over Italian foundation's stem-cell treatments
141 PUBLISHING
Open-access library for physics
starts up with reduced capacity
142 PHARMACEUTICALS
World Health Organization's bid to
tackte orphan diseases draws fire
143 EARTH SCIENCE
Mini-satellites provide near real-time images of Earth
144 RESEARCH FUNDING
China overtakes Europe in percentage spend on R&D
FEATURES
146 COMPUTER SCIENCE
The learning machines
By sifting through massive amounts of data, computers are edging towards artificial intelligence
BOOKS & ARTS
156 MILITARY SCIENCE
The evolving science of war Sharon Weinberger
157 PSYCHOLOGY Feeling the fear David Adam
15B ORNITHOLOGY Under their wing Ben Sheldon
Tinnitus tunesmith Non-sufferers can learn from Daniel Fishkin's series of installations, Composing the Tinnitus Suites
CORRESPONDENCE
16O Towards effective general ecosystem models / Self-referential citation should not count / Himalayan network needs support / Pollinator decline estimated
NEW ONLINE
161 Papers published this week at nature.con
NEWS & VIEWS
I62 FORUM: DEVELOPMENTAL BIOLOGY Tethered wings
Drosophila wings develop even when Wingless protein cannot spread Gines Morata; Gary Struhl
SEE ARTICLE P.180
163 ELECTROCHEMISTRY
Metal-free energy storage
A non-metallic electroactive material
for flow batteries
Grigorii L Soloveichik SEE LETTER R195
I65 THERAPEUTlCS
Detective work on drug dosage A device that tracks drug levels in blood in real time
Richard M Crooks
I66 QUANTUM PHYSICS An atomic SQUID An analogue of a superconducting device based on ultracold atoms Charles A Sackett
167 HIV
Ringside views
Binding of Vif or Vpx mediates
ubiquitination of restriction factors Michael H Malim
SEE LETTERS P.229 & R234
ARTICLES
169 AGEING Diversity of ageing across
the tree of life n
'Face-to-face' transfeelSr4,'
device-ready graphite sheets PAGE 190
174 GENOMICS Elephant shark genome provides unique insights into gnathostome evolution
B Venkatesh et al.
18O DEVELOPMENTAL BIOLOGY Patterning and growth control by membranetethered Wingless
C Alexandre, A Baena-Lopez
&J-P Vincent SEE N&V R162
LETTERS
I86 ASTROPHYSICS The rarity of dust in metal-poor galaxies
D B Fisher et al.
I9O MATERIALS Face-to-face transfer of wafer-scale graphene films L Gao et al.
195 ELECTROCHEMISTRY A metal-free organic-inorganic aqueous flow battery
B Huskinson et al. SEE N&V P. 163
199 CHEMISTRY Merging allylic carbonhydrogen and selective carboncarbon Bond activation
A Masarwa et al.
2O4 OCEANOGRAPHY Primitive layered gabbros from fast-spreading lower oceanic crust
K M Gillis et al.
2OB GENETICS The effects of genetic
variation on gene expression dynamics during development
M Francesconi & B Lehner 2
212 CANCER HMGA2 functions as a
competing endogenous RNA to
promote lung cancer progression
MS Kumar et al. .
0
21B IMMUNOLOGY Mycobacteria manipulate
macrophage recruitment through
coordinated use of membrane lipids
CJ Cambier et al.
223 NEUROSCIENCE Transcranial
amelioration of inflammation and cell
death alter brain injury
T L Roth et al.
229 STRUCTURAL BIOLOGY Structural basis
for hijacking CBF-13 and CUL5 E3
ligase complex by HIV-1 Vif
YGuo et al. SEE N&V P.167
234 STUCTURAL BIOLOGY Structural basis of lentiviral subversion of a cellular protein degradation pathway D Schwefel et al. SEE N&V R167
239 BIOTECHNOLOGY Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform M Enquist-Newman et al.
244 STRUCTURAL BIOLOGY De novo protein
crystal structure determination from X-ray free-electron laser data
T R M Barends et al.
248 CORRIGENDUM The zebrafish reference genome sequence and its relationship to the human genome
K Howe et al.
Dust buster
Local observations suggest distant galaxies are not so dusty. PAGE186
Analysis of the genome of the elephant shark, a native of temperate waters off southern Australia and New Zealand, Shows it to be the slowest evolving vertebrate known, coelacanth
included. lt has an unusual
adaptive immune system and lacks genes for calcium-binding phosphoproteins, in line with the
absence of bone -'
in catlaginous 40
fish.
nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE
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