Climate policy: Streamline IPCC reports
As the Intergovernmental Panel on Climate Change asks how its assessment process should evolve, Dave Griggs argues for decadal updates and eased workloads.
Global warming: Improve economic models of climate change
Costs of carbon emissions are being underestimated, but current estimates are still valuable for setting mitigation policy, say Richard L. Revesz and colleagues.
Biotechnology: Recombinant gold
Nathaniel Comfort applauds a nuanced history of genetic engineering's early years.
Review of Gene Jockeys: Life Science and the Rise of Biotech Enterprise
Nicolas Rasmussen
Ecology: Wilson in Africa
Stuart Pimm enjoys a fellow naturalist's first visit to sub-Saharan Africa, and the global lessons drawn from it.
Review of A Window on Eternity: A Biologist's Walk Through Gorongosa National Park
Edward O. Wilson
New in paperback
Highlights of this season's releases
Climate Economics: A strained relationship
Scott Barrett examines a study probing the nexus between climate change and energy.
Review of Planetary Economics: Energy, Climate Change and the Three Domains of Sustainable Development
Michael Grubb, Jean-Charles Hourcade & Karsten Neuhoff
Medicine: Outside the fold
Giovanna Mallucci assesses the autobiography of Stanley Prusiner, the discoverer of prions.
Review of Madness and Memory: The Discovery of Prions — A New Biological Principle of Disease
Stanley B. Prusiner
Drugs: Gut response
Maryn McKenna finds much to digest in a warning about the demise of our bodily bacteria.
Review of Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues
Martin J. Blaser
Education: Digital lessons learned
Robert Lue enjoys a deft study of online pedagogy.
Review of The War on Learning: Gaining Ground in the Digital University
Elizabeth Losh
Energy: The new oil era
Chris Nelder relishes a lively history of fracking that delves into the complexities.
Review of The Boom: How Fracking Ignited the American Energy Revolution and Changed the World
Russell Gold
Solar system: Cracking up on asteroids
Heather A. Viles
See also
Letter by Delbo et al.
Cancer: Damage prevention targeted
Dan Dominissini &
Chuan He
See also
Article by Gad et al.
See also
Article by Huber et al.
Biogeoscience: Africa's greenhouse-gas budget is in the red
Cheikh Mbow
Metabolism: Targeting a fat-accumulation gene
Charles Brenner
See also
Letter by Kraus et al.
Quantum physics: A strong hybrid couple
Luming Duan
See also
Letter by Reiserer et al.
See also
Letter by Tiecke et al.
Structural biology: The purple heart of photosynthesis
Richard J. Cogdell &
Aleksander W. Roszak
See also
Article by Niwa et al.
Articles
Top
Transcriptional landscape of the prenatal human brain
Jeremy A. Miller,
Song-Lin Ding,
Susan M. Sunkin,
Kimberly A. Smith,
Lydia Ng
+ et al.
A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.
A mesoscale connectome of the mouse brain
Seung Wook Oh,
Julie A. Harris,
Lydia Ng,
Brent Winslow,
Nicholas Cain
+ et al.
In mouse, an axonal connectivity map showing the wiring patterns across the entire brain has been created using an EGFP-expressing adeno-associated virus tracing technique, providing the first such whole-brain map for a vertebrate species.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Helge Gad,
Tobias Koolmeister,
Ann-Sofie Jemth,
Saeed Eshtad,
Sylvain A. Jacques
+ et al.
In order to find a general treatment for cancer, this study found that MTH1 activity is essential for the survival of transformed cells, and isolated two small-molecule inhibitors of MTH1, TH287 and TH588 — in the presence of these inhibitors, damaged nucleotides are incorporated into DNA only in cancer cells, causing cytotoxicity and eliciting a beneficial response in patient-derived mouse xenograft models.
See also
News & Views by Dominissini & He
See also
Article by Huber et al.
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Kilian V. M. Huber,
Eidarus Salah,
Branka Radic,
Manuela Gridling,
Jonathan M. Elkins
+ et al.
A chemoproteomic screen is used here to identify MTH1 as the target of SCH51344, an experimental RAS-dependent cancer drug; a further search for inhibitors revealed (S)-crizotinib as a potent MTH1 antagonist, which suppresses tumour growth in animal models of colon cancer, and could be part of a new class of anticancer drugs.
See also
News & Views by Dominissini & He
See also
Article by Gad et al.
Structure of the LH1–RC complex from Thermochromatium tepidum at 3.0 Å
Satomi Niwa,
Long-Jiang Yu,
Kazuki Takeda,
Yu Hirano,
Tomoaki Kawakami
+ et al.
The near-atomic-level structure of a complete bacterial light-harvesting antenna–reaction centre (LH1–RC) complex is described here; the structure reveals how energy is transferred from the LH1 to the RC in a highly efficient way and suggests how ubiquinone might cross a closed LH1 barrier.
See also
News & Views by Cogdell & Roszak
Letters
Top
Thermal fatigue as the origin of regolith on small asteroids
Marco Delbo,
Guy Libourel,
Justin Wilkerson,
Naomi Murdoch,
Patrick Michel
+ et al.
Thermal fatigue resulting from diurnal temperature variations is shown to be the dominant means of rock fragmentation and, consequently, regolith formation on small asteroids.
See also
News & Views by Viles
A quantum gate between a flying optical photon and a single trapped atom
Andreas Reiserer,
Norbert Kalb,
Gerhard Rempe &
Stephan Ritter
Quantum gates — in which stationary quantum bits are combined with ‘flying’ quantum bits, that is, photons — will be essential in quantum networks; such a gate, between a laser-trapped atomic quantum bit and a single photon, is now reported.
See also
News & Views by Duan
See also
Letter by Tiecke et al.
Nanophotonic quantum phase switch with a single atom
T. G. Tiecke,
J. D. Thompson,
N. P. de Leon,
L. R. Liu,
V. Vuletić
+ et al.
Strongly coupling a photon to a single atom trapped in the near field of a nanoscale photonic crystal cavity results in a light switch which can be turned on and off with a single photon.
See also
News & Views by Duan
See also
Letter by Reiserer et al.
Dynamics of continental accretion
L. Moresi,
P. G. Betts,
M. S. Miller &
R. A. Cayley
Three-dimensional dynamic computer models show how accretionary tectonic margins evolve from the initial plate-collision state, through a period of plate margin instability, and then re-establish a stable convergent margin; the models illustrate how significant curvature of the orogenic system develops, as well as the mechanism for tectonic escape of the back-arc region.
Detection and replication of epistasis influencing transcription in humans
Gibran Hemani,
Konstantin Shakhbazov,
Harm-Jan Westra,
Tonu Esko,
Anjali K. Henders
+ et al.
Epistasis has rarely been shown among natural polymorphisms in human traits; this research using advanced computation and gene expression data reveals many instances of epistasis between common single nucleotide polymorphisms in humans, with epistasis and the direction of its effect replicating in independent cohorts.
A synchronized global sweep of the internal genes of modern avian influenza virus
Michael Worobey,
Guan-Zhu Han &
Andrew Rambaut
A local molecular clock approach shows that most genetic diversity in avian influenza virus (AIV) arose in a recent global sweep and that avian strains are the sister group to equine H7N7; most of the 1918 pandemic virus’s genes originated from the resulting western hemispheric AIV lineage.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
Daniel Kraus,
Qin Yang,
Dong Kong,
Alexander S. Banks,
Lin Zhang
+ et al.
Nicotinamide N-methyltransferase (NNMT) expression is increased in white adipose tissue and liver of obese and diabetic mice, Nnmt knockdown protects against diet-induced obesity by altering the availability of adipose S-adenosylmethionine and NAD+, rendering Nnmt a novel target for treating obesity and type 2 diabetes.
See also
News & Views by Brenner
ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
Hong Wen,
Yuanyuan Li,
Yuanxin Xi,
Shiming Jiang,
Sabrina Stratton
+ et al.
Candidate tumour suppressor ZMYND11 specifically recognizes histone K36 trimethylation on the histone variant H3.3 and helps regulate transcription elongation.
Direct measurement of local oxygen concentration in the bone marrow of live animals
Joel A. Spencer,
Francesca Ferraro,
Emmanuel Roussakis,
Alyssa Klein,
Juwell Wu
+ et al.
Here, using two-photon phosphorescence lifetime microscopy, the local oxygen tension in the bone marrow of live mice is found to be quite low, with spatiotemporal variations depending on the blood vessel type, distance to the endosteum, and changes in cellularity after stress.
nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE
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- Verlag:
- NPG Nature publishing group
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- B00042583
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