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nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE

Vol 511, No. 7511, Juli 2014, The Road Most Taken


    Public health: A sustainable plan for China's drinking water

    Tackling pollution and using different grades of water for different tasks is more efficient than making all water potable, say Tao Tao and Kunlun Xin.
    Diversity: Energy studies need social science

    A broader pool of expertise is needed to understand how human behaviour affects energy demand and the uptake of technologies, says Benjamin K. Sovacool.
Neuroscience: Looking-glass wars

Patricia Smith Churchland welcomes a critique of the mirror-neuron theory linking brain and behaviour.

    Review of The Myth of Mirror Neurons: The Real Neuroscience of Communication and Cognition
    Gregory Hickok

Palaeoclimate science: Causes and effects of Antarctic ice

    Dan Lunt

See also

        Letter by Goldner et al.

HIV: The mixed blessing of interferon

    Amalio Telenti

See also

        Letter by Sandler et al.

Quantum physics: The path most travelled

    Adrian Lupascu

See also

        Letter by Weber et al.

50 & 100 Years ago
Epigenetics: Cellular memory erased in human embryos

    Wolf Reik &
    Gavin Kelsey

See also

        Letter by Smith et al.

See also

        Letter by Guo et al.
Articles
Top

    Comprehensive molecular profiling of lung adenocarcinomaOpen
        The Cancer Genome Atlas Research Network

    An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.
    Topoisomerase II mediates meiotic crossover interference
        Liangran Zhang,
        Shunxin Wang,
        Shen Yin,
        Soogil Hong,
        Keun P. Kim
        + et al.

    Topoisomerase II mediates meiotic crossover interference by adjusting the protein/DNA meshwork of chromosome axes.
    Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
        Andrew S. Doré,
        Krzysztof Okrasa,
        Jayesh C. Patel,
        Maria Serrano-Vega,
        Kirstie Bennett
        + et al.

    An X-ray structure is presented for metabotropic glutamate receptor 5, a class C G-protein-coupled glutamate receptor linked to fragile X syndrome and neurological disorders; this study provides insights into the protein’s mechanism of action.

Letters
Top

    Velocity anti-correlation of diametrically opposed galaxy satellites in the low-redshift Universe
        Neil G. Ibata,
        Rodrigo A. Ibata,
        Benoit Famaey &
        Geraint F. Lewis

    Measurements of the velocities of pairs of diametrically opposed satellite galaxies of host galaxies in the local Universe show that satellite pairs out to a distance of 150 kiloparsecs from their hosts are anti-correlated in their velocities and that galaxies in the larger-scale environment are strongly clumped along the axis joining the inner satellite pair.
    Misaligned protoplanetary disks in a young binary star system
        Eric L. N. Jensen &
        Rachel Akeson

    Observations show that one or both of the protoplanetary disks in the young binary system HK Tauri are significantly inclined to the binary orbital plane, demonstrating that the necessary conditions exist for the misalignment-driven mechanisms thought to produce the unusual orbits of some extrasolar planets.
    Mapping the optimal route between two quantum states
        S. J. Weber,
        A. Chantasri,
        J. Dressel,
        A. N. Jordan,
        K. W. Murch
        + et al.

    Reconstruction of the quantum trajectories of a superconducting circuit that evolves under the competing influences of continuous weak measurement and Rabi drive makes it possible to deduce the most probable path through quantum state space.

    See also
            News & Views by Lupascu

    Antarctic glaciation caused ocean circulation changes at the Eocene–Oligocene transition
        A. Goldner,
        N. Herold &
        M. Huber

    A climate model is used to show that the growth of the Antarctic ice sheet at about 34 Myr ago drove changes in ocean circulation, but the opening of ocean gateways had relatively little impact.

    See also
            News & Views by Lunt

    Widespread mixing and burial of Earth’s Hadean crust by asteroid impacts
        S. Marchi,
        W. F. Bottke,
        L. T. Elkins-Tanton,
        M. Bierhaus,
        K. Wuennemann
        + et al.

    A new bombardment model of the early Earth, calibrated with existing lunar and terrestrial data, shows that the Earth’s surface would have been widely reprocessed by impacts through mixing and burial by impact-generated melt; the model may also explain the age distribution of ancient zircons and the absence of early terrestrial rocks.
    Seasonal not annual rainfall determines grassland biomass response to carbon dioxide
        Mark J. Hovenden,
        Paul C. D. Newton &
        Karen E. Wills

    Large annual variation in the stimulation of above-ground biomass by elevated carbon dioxide in a mixed C3/C4 temperate grassland can be predicted accurately using seasonal rainfall totals.
    PTEX is an essential nexus for protein export in malaria parasites
        Brendan Elsworth,
        Kathryn Matthews,
        Catherine Q. Nie,
        Ming Kalanon,
        Sarah C. Charnaud
        + et al.

    This paper demonstrates that a protein complex known as PTEX translocates all malaria parasite proteins destined for export into the cytosol of their host red blood cell.

    See also
            News & Views by Desai & Miller

    See also
            Letter by Beck et al.

    PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes
        Josh R. Beck,
        Vasant Muralidharan,
        Anna Oksman &
        Daniel E. Goldberg

    Plasmodium parasites, the causative agent of malaria, infect and remodel red blood cells by exporting hundreds of proteins into the red blood cell cytosol, a topological conundrum given that the parasite resides in a compartment known as the parasitophorous vacuole; here a dihydrofolate-reductase-based destabilization domain approach is used to inactivate HSP101, part of the Plasmodium translocon of exported proteins, and to demonstrate that it is required for the secretion of all classes of exported Plasmodium proteins.

    See also
            News & Views by Desai & Miller

    See also
            Letter by Elsworth et al.

    Equalizing excitation–inhibition ratios across visual cortical neurons
        Mingshan Xue,
        Bassam V. Atallah &
        Massimo Scanziani

    Different amounts of excitation received by different pyramidal cells of primary visual cortex are matched by proportional amounts of inhibition.
    Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression
        Netanya G. Sandler,
        Steven E. Bosinger,
        Jacob D. Estes,
        Richard T. R. Zhu,
        Gregory K. Tharp
        + et al.

    The timing of type I interferon signalling determines the disease course of SIV infection.

    See also
            News & Views by Telenti

    The DNA methylation landscape of human early embryos
        Hongshan Guo,
        Ping Zhu,
        Liying Yan,
        Rong Li,
        Boqiang Hu
        + et al.

    Base-resolution maps of DNA methylation in human gametes and early embryos offer novel insights into human methylation dynamics and the functional relationship between DNA methylation and gene expression.

    See also
            Letter by Smith et al.

    See also
            News & Views by Reik & Kelsey

    DNA methylation dynamics of the human preimplantation embryo
        Zachary D. Smith,
        Michelle M. Chan,
        Kathryn C. Humm,
        Rahul Karnik,
        Shila Mekhoubad
        + et al.

    Genome-scale DNA methylation maps over early human embryogenesis and embryonic stem cell derivation provide insights into shared and unique modes of regulation when compared to the mouse model, including relationships to gene expression, transposable element activity, and maternal-specific methylation.

    See also
            Letter by Guo et al.

    See also
            News & Views by Reik & Kelsey

    Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
        Nicholas Kwiatkowski,
        Tinghu Zhang,
        Peter B. Rahl,
        Brian J. Abraham,
        Jessica Reddy
        + et al.

    Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs.

Englische Ausgabe. Verlag: NPG Nature publishing group.

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